Associations Between the Gut Microbiota, Ultra-Processed Food Intake, and Gastrointestinal Tract Symptoms in Patients with Systemic Sclerosis

Poster presenter: Ju Young “Sally” Lee, BA, Medical Student, David Geffen School of Medicine, the University of California, Los Angeles

Poster title: Associations Between the Gut Microbiota, Ultra-Processed Food Intake, and Gastrointestinal Tract Symptoms in Patients with Systemic Sclerosis

Poster session B: Sunday, Nov. 17

What is your poster about? 
“My poster investigates whether increased consumption of ultra-processed food has any effects on the gut microbiome or gastrointestinal symptoms, such as diarrhea or bloating, on patients with systemic sclerosis.”

Why did you decide to investigate this topic? 
“Our gut microbiomes play a much larger role in our overall health than we once thought, influencing everything from mood and inflammation to the development of chronic conditions. At the same time, our diets have a significant impact on the composition and function of our microbiomes. With processed foods, artificial sweeteners, and additives becoming increasingly common in our diets, I wanted to investigate how this consumption affects our gut microbiota and, in turn, the symptoms people experience. Since patients with systemic sclerosis already show differences in their gut microbiomes compared to healthy individuals, I was particularly interested in understanding how diet might further influence these changes.”

What are you working on next related to this research? 
“Building on my interest in the impact of lifestyle and social factors on disease, I’m currently working on a study that examines the prevalence of psychosocial trauma in patients with systemic sclerosis. Research increasingly shows that stress and trauma can lead to inflammatory changes and negatively impact the immune system, potentially influencing the development and progression of autoimmune diseases. I believe that by exploring this connection further, we can develop therapies aimed at reducing disease burden through stress management.” 

What excites you most about your work? 
“What excites me most about this research is the opportunity to make a real difference in how we manage and prevent autoimmune diseases. Growing up, I saw firsthand how my mother’s lupus controlled so much of her life, and the fear of flares was always present. Now, being able to study how everyday factors like diet, lifestyle, and stress can influence disease outcomes is incredibly empowering. It feels like we’re moving toward giving patients more tools and options to manage their conditions, rather than just reacting to symptoms. This research also has the potential to drive policy changes, bringing better resources and preventive care to underserved communities, which could have a lasting impact on the health of future generations.”

What are you most looking forward to at ACR Convergence 2024 in Washington, D.C.?
“Rheumatology is advancing at a dizzying pace. I’m so excited to see what the latest updates are and learn from the experts leading it in hopes that I get more inspiration for my future career path!”